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Gamma Knife Radiosurgery

Whole-procedural Radiological Accuracy for Delivering Multi-session Gamma Knife Radiosurgery With a Relocatable Frame System (403-408)

A newly developed Gamma Knife relocatable eXtend frame system has enabled the delivery of multi-session Gamma Knife radiosurgery without the use of skull pin fixation frame system. In this study, we investigate and report for the first time the whole procedural radiological accuracy for administering such treatments. To quantify the radiological alignment, the commonly used Winston-Lutz test was modified and used to determine the device accuracy of the eXtend frame system. Patient setup uncertainties relative to the device were further measured for a series of treatment sessions (n = 58), and then incorporated with the Winston-Lutz test results from individual patient-specific eXtend frame systems. The whole-procedure mean 3D radiological setup uncertainty was determined to be 0.69 ± 0.73 mm (1σ) from all the cases analyzed, and the mean 90% confidence level margins were found to be 0.55, 0.78 and 0.72 mm along the x-, y-, and z-axis, respectively. Our results therefore demonstrated that sub-millimetric radiological accuracy is clinically achievable for multi-session Gamma Knife radiosurgery treatments and a 1 mm margin along the major axes is sufficient for planning multi-session Gamma Knife radiosurgery treatments.

Key words: Stereotactic radiosurgery; Gamma Knife; eXtend System; Relocatable frame; Accuracy.

This article can be cited as:
Ma, L., Pinnaduwage, D., McDermott, M., Sneed, P.K. Whole-procedural Radiological Accuracy for Delivering Multi-session Gamma Knife Radiosurgery With a Relocatable Frame System. Technol Cancer Res Treat. 13, 403-408 (2014) DOI: 10.7785/tcrtexpress.2013.600259


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This article can be accessed at PubMed:

Received: January 22, 2013; Revised; March, 9 2013; Accepted: March 11, 2013; Published in TCRT Express on: April 02 2013

TCRT October 2014

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Volume 13
No. 5 (386-484)
October 2014
ISSN 1533-0338

DOI: 10.7785/tcrtexpress.2013.600259

Lijun Ma, Ph.D.1*
Dilini Pinnaduwage, Ph.D.1
Michael McDermott, M.D.2
Penny K. Sneed, M.D.1

1Department of Radiation Oncology, University of California, San Francisco, CA 94143
2Department of Neurosurgery, University of California, San Francisco, CA 94143

Open Access Article
The authors, the publisher, and the right holders grant the right to use, reproduce, and disseminate the work in digital form to all users.


*Corresponding author: Professor Lijun Ma, Ph.D.
Phone: 415-353-8932
Fax: 415-353-8679
E-mail: lijunma@radonc.ucsf.edu