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Cancer Watch

Using In-Vivo Fluorescence Imaging in Personalized Cancer Diagnostics and Therapy, an Image and Treat Paradigm (549-560)

The major goal in developing drugs targeting specific tumor receptors, such as Monoclonal AntiBodies (MAB), is to make a drug compound that targets selectively the cancer-causing biomarkers, inhibits their functionality, and/or delivers the toxin specifically to the malignant cells. Recent advances in MABs show that their efficacy depends strongly on characterization of tumor biomarkers. Therefore, one of the main tasks in cancer diagnostics and treatment is to develop non-invasive in-vivo imaging techniques for detection of cancer biomarkers and monitoring their down regulation during the treatment. Such methods can potentially result in a new imaging and treatment paradigm for cancer therapy. In this article we have reviewed fluorescence imaging approaches, including those developed in our group, to detect and monitor Human Epidermal Growth Factor 2 (HER2) receptors before and during therapy. Transition of these techniques from the bench to bedside is the ultimate goal of our project. Similar approaches can be used potentially for characterization of other cancer related cell biomarkers.

Key words: Fluorescence imaging; Near infrared optical imaging; Targeted fluorescent probe; Affibody; Cancer treatment; Cancer diagnostics; Human epidermal growth factor receptor.





This article can be cited as:
Ardeshirpour, Y., Chernomordik, V., Capala, J., Hassan, M., Zielinsky, R., Griffiths, G., Achilefu, S., Smith, P., Gandjbakhche, A. Using In-Vivo Fluorescence Imaging in Personalized Cancer Diagnostics and Therapy, an Image and Treat Paradigm Technol Cancer Res Treat. 10, 549-560 (2011). DOI: 10.7785/tcrt.2012.500221

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Received: June 23, 2011; Revised: August 30, 2011; Accepted: October 6, 2011

TCRT December 2011

category image
Volume 10
No.6 (505-634)
December 2011
ISSN 1533-0338

DOI: 10.7785/tcrt.2012.500221

Yasaman Ardeshirpour, Ph.D.1
Victor Chernomordik, Ph.D.1
Jacek Capala, Ph.D.2
Moinuddin Hassan, Ph.D.1
Rafal Zielinsky, Ph.D.2
Gary Griffiths, Ph.D.3
Samuel Achilefu, Ph.D.4
Paul Smith, Ph.D.5
Amir Gandjbakhche, Ph.D.1*

1NIH/National Institute of Child Health and Human Development, Building 9, 9 Memorial Dr., Bethesda, MD 20892
2NIH/National Cancer Institute, Building 10-Magnuson Clinical Center, 10 Center Dr., Bethesda, MD 20892
3NIH/Imaging Probe Development Center, Building 9800, Medical Center Dr., Rockville, MD 20850
4Optical Radiology Lab, Department of Radiology, Washington University, 4525 Scott Avenue, St. Louis, MO 63110.
5NIH/National Institute of Biomedical Imaging and Bioengineering, Building 13, 3N18A 13 South Dr., Bethesda, MD 20892

*Corresponding author:
Amir Gandjbakhche, Ph.D.
E-mail: gandjbaa@mail.nih.gov