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Apparatus-Dependent Dosimetric Differences in Spine Stereotactic Body Radiotherapy (563-574)

The purpose of this investigation was to study apparatus-dependent dose distribution differences specific to spine stereotactic body radiotherapy (SBRT) treatment planning. This multi-institutional study was performed evaluating an image-guided robotic radiosurgery system (CK), intensity modulated protons (IMP), multileaf collimator (MLC) fixed-field IMRT with 5 mm (11 field), 4 mm (9 field), and 2.5 mm (8- and 9-field) leaf widths and intensity modulated volumetric arc therapy (IMVAT) with a 2.5 mm MLC. Treatment plans were systematically developed for targets consisting of one, two and three consecutive thoracic vertebral bodies (VBs) with the esophagus and spinal cord contoured as the organs at risk. It was found that all modalities achieved acceptable treatment planning constraints. However, following normalization fixed field IMRT with a 2.5 mm MLC, IMVAT and IMP systems yielded the smallest ratio of maximum dose divided by the prescription dose (MD/PD) for one-, two- and three-VB PTVs (ranging from 1.1-1.16). The 2.5 mm MLC 9-field IMRT, IMVAT and CK plans resulted in the least dose to 0.1 cc volumes of spinal cord and esophagus. CK plans had the greatest degree of target dose inhomogeneity. As the level of complexity increased with an increasing number of vertebral bodies, distinct apparatus features such as the use of a high number of beams and a finer leaf size MLC were favored. Our study quantified apparatus-dependent dose-distribution differences specific to spine SBRT given strict, but realistic, constraints and highlights the need to benchmark physical dose distributions for multi-institutional clinical trials.

Key words: Treatment planning; Spine; Stereotactic body radiotherapy; Protons; Radiosurgery.




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TCRT December 2010

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Volume 9
No. 6 (539-656)
December 2010
ISSN 1533-0338

DOI: 10.7785/tcrt.2012.500167

Lijun Ma, Ph.D.1
Arjun Sahgal, M.D.2*
Luca Cozzi, Ph.D.3
Eric Chang, M.D.4
Almon Shiu, Ph.D.5
Daniel Létourneau, Ph.D.6
Fang-Fang Yin, Ph.D.7
Antonella Fogliata, Ph.D.3
Wolfgang Kaissl, Ph.D.8
Derek Hyde, Ph.D.9
Normand J. Laperriere, M.D.6
Dennis C. Shrieve, M.D., Ph.D.10
David A. Larson, M.D., Ph.D.1

1Department of Radiation Oncology, University of California San Francisco, San Francisco, California, USA
2Department of Radiation Oncology, Princess Margaret Hospital, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
3Oncology Institute of Southern Switzerland, Medical Physics Unit, Bellinzona, Switzerland
4Department of Radiation Oncology, M.D. Anderson Cancer Center, University of Texas, Texas, USA
5Department of Radiation Physics, M.D. Anderson Cancer Center, University of Texas, Texas, USA

Arjun.sahgal@rmp.uhn.on.ca