About TCRT

TCRT has been on continuous publication since 2002. It is covered currently by all the major data systems such as Medline, PubMed, Web of Science, Thomson's ISI and SCI and Scopus.

The 2012 Impact factor for TCRT is 1.943

TCRT Open Access
TCRT seeks original articles
Cancer Watch

Hypofractionated Extracranial Stereotactic Radiotherapy Boost For Gynecologic Tumors: A Promising Alternative To High-Dose Rate Brachytherapy (509-514)

The purpose of this study is to report toxicity and outcome results in patients with gynaecological tumours treated with a final boost using extra-cranial stereotactic radiotherapy (SRT) with a linac-based micro-multileaf collimator technique as an alternative to high-dose rate brachytherapy (HDR-BT). Since January 2002, 26 patients with either endometrial (n = 17) or cervical (n = 9) cancer were treated according to this protocol: 45-50.4 Gy external radiotherapy (RT) to the pelvic ± para-aortic regions followed by a final SRT boost of 2 x 7 Gy to the vaginal vault (4-7 day interval between fractions). Median age was 62 years (37-74 range). Fifteen patients were diagnosed with adenocarcinoma, 7 with squamous-cell carcinoma, and 4 with sarcoma. FIGO stage I (n = 17), stage II (n = 7), and stage III (n = 2). Toxicity was scored according to RTOG/EORTC criteria.

No severe (>grade-3) acute urinary or low-gastrointestinal (GI) toxicity was observed during treatment and up to 3 months after treatment completion. Moderate (grade ≤ 3) acute urinary or low-GI toxicity was observed in 23% and 35% of patients, respectively. After a median follow-up of 47 months (4-77, range), late urinary, low-GI, and sexual ≥grade-2 (worst score) has been reported in 4%, 12% and 29.4% of patients, respectively. The 3-year loco-regional failure-free and overall survival rates were 96% and 95%, respectively. Preliminary results on feasibility, tolerance, and outcome with SRT are encouraging and may be considered a sound alternative to HDR-BT for gynecologic tumors.

Key words: Extracranial stereotactic radiotherapy; cervix cancer; endometrial adeno­carcinoma; micromultileaf collimator; high-dose rate brachytherapy.

Purchase Downloadable PDF of Article

Corporate User


University/Academic User


TCRT October 2010

category image

Volume 9
No. 5 (431-538)
October 2010
ISSN 1533-0338

Sandra Jorcano, M.D.1
Meritxell Mollà, M.D.1
Lluís Escudé, D.Sc.1
Sergi Sanz, D.Sc.2
Alberto Hidalgo, M.D.3
Jose Ignacio Toscas, M.D.1
Dolors Linero, D.Sc.1
Raymond Miralbell, M.D.1,4,*

1Servei de Radio-oncologia, Institut Oncològic Teknon, Vilana 12, 08022 Barcelona-E, Spain
2Statistics Department, Barcelona Centre for International Health Research. Villaroel 170, 08036 Barcelona-E, Spain
3Servei de Radiodiagnostic, Centro Médico Teknon, Vilana 12, 08022 Barcelona-E, Spain
4Service de Radio-oncologie, Hôpitaux Universitaires, Rue Micheli-du-Crest 24. 1211 Genève-CH, Switzerland