a bi-monthly peer-reviewed research journal
TCRT August 2010
Volume 9No. 4 (317-430) August 2010 ISSN 1533-0338
PET/CT Imaging Target Volume Delineation for Preoperative Radiotherapy of Rectal Cancer: Inter-Observer Variability and Potential Impact of FDG-PET/CT Imaging (393-398)To analyze the inter-observer variability and the potential impact of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) imaging for target volume delineation in preoperative radiotherapy of rectal cancer. Gross tumor volume (GTV) and clinical target volume (CTV) in 2 cases of rectal cancer were contoured by 10 radiation oncologists, 5 on CT and 5 on PET/CT images. Resulting volumes were analyzed by coefficient of variation (CV) and concordance index (CI). Mean GTV was 120 cc ± 20.4 cc in case A and 119 cc ± 35.7 cc in case B. Mean CTV was 723 cc ± 147.5 cc in case A and 739 cc ± 195.6 cc in case B. CV was lower and CI was similar or higher across the observers contouring GTV on PET/CT. CTV variability was less influenced by the use of PET/CT. PET/CT may allow reducing inter-observer variability in GTV delineation.
Key words: Observer variability; PET/CT; Rectal Cancer; Radiotherapy; Treatment planning. Marco Krengli, M.D.1 1Radiotherapy, University Hospital Maggiore della Carità, via Solaroli 17, 28100 Novara, Italy Subscription is more cost effective than purchasing PDFs on-the-fly. Click here for details. |
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