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Combined Fluorescence and X-Ray Tomography for Quantitative In Vivo Detection of Fluorophore (45-52)
Initial results from a novel dual modality preclinical imager which combines non-contact fluorescence tomography (FT) and x-ray computed tomography (CT) for preclinical functional and anatomical in vivo imaging are presented. The anatomical data from CT provides a priori information to the FT reconstruction to create overlaid functional and anatomical images with accurate localization and quantification of fluorophore distribution. Phantoms with inclusions containing Indocyanine-Green (ICG), and with heterogeneous backgrounds including iodine in compartments at different concentrations for CT contrast, have been imaged with the dual modality FT/CT system. Anatomical information from attenuation maps and optical morphological information from absorption and scattering maps are used as a priori information in the FT reconstruction. Although ICG inclusions can be located without the a priori information, the recovered ICG concentration shows 75% error. When the a priori information is utilized, the ICG concentration can be recovered with only 15% error. Developing the ability to accurately quantify fluorophore concentration in anatomical regions of interest may provide a powerful tool for in vivo small animal imaging.
Key words: Fluorescence Tomography; Diffuse Optical Tomography; X-Ray Computed Tomography.
TCRT February 2010
No. 1 (p. 1-106)
Featured ImageOzyigit, G., Cengiz, M, Hurmuz, P, Yazici, G, Gultekin, M, Akyol, F., Yildiz, F, Gurkaynak, M, Zorlu, F. (2013) Robotic Stereotactic Radiosurgery in Patients with Nasal Cavity and Paranasal Sinus Tumors. Technol Cancer Res Treat Ahead of Print Aug. 31 2013. http://www.tcrt.org/product-18090.html