TCRT June 2009

Volume 8
No. 3 (p 177-248)
June 2009
ISSN 1533-0338

Tumor marker

The Correlation Between GPR30 and Clinicopathologic Variables in Breast Carcinomas (p. 231-234)

The G-protein-coupled-receptor 30 (GPR30) is a new membrane estrogen receptor. The aim of the present study was to determine the correlations among GPR30, ERα, PR, C-erbB-2, p53, TNM stage, and pathologic grade in breast carcinomas. Two hundred forty-one biopsy specimens were evaluated with immunohistochemical assays, and then correlations were analyzed. Low negative correlations of GPR30 with ERα (r = -0.144, P<0.05) and PR (r = -0.214, P<0.01) were observed. Associations of GPR30 with C-erbB-2, p53, TNM stage, and pathologic grade were not confirmed. These findings indicated that GPR30 might be an independent prognostic factor in breast carcinomas.

Key Words: GPR30; Breast carcinoma; Clinicopathological variable; Correlation.

Gang Tu, MD, Ph.D.^1,a
Dingrong Hu, BSc^2,a
Guanglun Yang, MD, Ph.D.¹
Tinghe Yu, MD, Ph.D.^2,*

¹Department of General Surgery
The First Affiliated Hospital
Chongqing Medical University
Chongqing 400010, China
²Institute of Ultrasound
Engineering in Medicine
Chongqing Medical University
Chongqing 400010, China

^aContributed equally to this paper.

*yutinghe@hotmail.com

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TCRT June 2009

The Correlation Between GPR30 and Clinicopathologic Variables in Breast Carcinomas (p. 231-234)

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