TCRT August 2005

category image Volume 4
No. 4 (p 311-454)
August 2005
ISSN 1533-0338
Optical Imaging

Spectral Polarization Imaging of Human Prostate Cancer Tissue Using a Near-infrared Receptor-targeted Contrast Agent (p. 429-436)

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue ?optical window?. The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

Keywords: Prostate cancer; Receptor-targeted; Peptide analogue conjugate; Contrast agent; Spectral polarization imaging; Near-infrared; Absorption; and Fluorescence.

Y. Pu, B.S.1
W. B. Wang, Ph.D.2
G. C. Tang, M.S.2
F. Zeng, B.S.2
S. Achilefu, Ph.D.3
J. H. Vitenson, M.D.4
I. Sawczuk, M.D.6
S. Peters, M.D.5
J. M. Lombardo, M.D.5
R. R. Alfano, Ph.D.2,*

1Department of Electrical Engineering
2Department of Physics
The City College of the City Univ. of NY
Convent Avenue at 138th Street
New York, NY 10031
3Washington University School of Medicine
4525 Scott Avenue
St. Louis. Missouri 63110
4Department of Urology
5Department of Pathology
Hackensack University Medical Center
30 Prospect Avenue
Hackensack, NJ 07601
6Department of Urology
Hackensack University Medical Center
Adjunct Professor of Urology
College of Physicians and Surgeons
Columbia University
Professor of Surgery (Urology)
UMDNJ Newark Medical School
*alfano@sci.ccny.cuny.edu

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