TCRT October 2008

Volume 7
No. 5 (p 341-414)
October 2008
ISSN 1533-0338

Pyrosequencing

AKT1 (E17K) Mutation in Pancreatic Cancer (p. 407-408)

The prevalence of a novel somatic mutation (E17K) in the pleckstrin homology domain of AKT1 was investigated in pancreatic cancer using a quantitative pyrosequencing assay. This mutation was un-detectable in pancreatic cancer tissue samples (n=65) and pancreatic cell line (n=10) DNA suggesting that pancreatic cancer progression is mainly dependent on the K-Ras mutation.

Key words: Pancreatic cancer; AKT1; Pyrosequencing.

Azim Mohamedali, Ph.D.¹
Nicholas C. Lea, Ph.D.¹
Roger M. Feakins, MD²
Kavita Raj, MD¹
Ghulam J. Mufti, MD¹
Hemant M. Kocher, MD^2,3,*

¹Department of Haematological Medicine
Kings College London
123 Coldharbour Lane
London
²Barts and the London HPB Centre
The Royal London Hospital
London
³Centre for Tumour Biology
Institute of Cancer, Barts and The London School of Medicine and Dentistry
London, UK
*Hemant.kocher@cancer.org.uk

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TCRT October 2008

AKT1 (E17K) Mutation in Pancreatic Cancer (p. 407-408)

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