About TCRT

TCRT has been on continuous publication since 2002. It is covered currently by all the major data systems such as Medline, PubMed, Web of Science, Thomson's ISI and SCI and Scopus.

The 2012 Impact factor for TCRT is 1.943

TCRT Open Access
TCRT seeks original articles
Cancer Watch
Open Access

A Study of the Immunological Response to Tumor Ablation with Irreversible Electroporation (p. 301-306)

Immune cell recruitment during the treatment of sarcoma tumors in mice with irreversible electroporation was studied by immunohistochemistry. Irreversible electroporation is a non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the membrane. Employing irreversible electroporation parameters known to completely ablate the tumors without thermal effects we did not find infiltration of immune cells probably because of the destruction of infiltration routes. We confirm here that immune response is not instrumental in irreversible electroporation efficacy, and we propose that irreversible electroporation may be, therefore, a treatment modality of interest to immunodepressed cancer patients.

Key words: Tumor ablation; Irreversible electroporation; Immunological response; Tumor infiltration; and Immunocytochemistry.




TCRT August 2007

category image
Volume 6
No. 4 (p 255-360)
August 2007
ISSN 1533-0338

B. Al-Sakere, M.D., M.Sc.1,2
C. Bernat, M.Sc.1,2
F. André, Ph.D.1,2
E. Connault, B.Sc.1,2
P. Opolon, M.D.1,2
R. V. Davalos, Ph.D.3
L. M. Mir, D.Sc.1,2,*

1UMR 8121 CNRS-Institut
Gustave-Roussy
39 rue C. Desmoulins
F-94805 Villejuif, France
2Univ Paris-Sud, UMR 8121
3School of Biomedical Engineering and Sciences
Virginia Tech-Wake Forest University
Blacksburg, Virginia 24061, USA
*luismir@igr.fr

Open Access Article
The authors, the publisher, and the right holders grant the right to use, reproduce, and disseminate the work in digital form to all users.

Click here to download PDF