The treatment of hematogenous brain metastases is a frequent indication for stereotactic radiosurgery (SRS). It is common for more than one metastasis to be treated during the same SRS session.

We retrospectively identified four cases where our m3 micro multileaf collimator (mMLC) was used to create two distinct apertures and treat adjacent lesions using a single isocenter. For these four cases, single isocenter plans with static conformal beams were dosimetrically compared to plans utilizing two isocenters with static conformal beams or conformal arcs.

The effects on dose homogeneity, dose conformity, and the minimum isodose separating the two targets are minor and variable. On the other hand, the use of a single isocenter technique consistently halves delivery time and decreases the integral dose to normal tissue.

For small adjacent metastases, which can simultaneously be encompassed within the high-resolution portion of the m3/Novalis mMLC collimator, the use of a single rather than a dual isocenter technique is feasible and generally advantageous.

Key words: Stereotactic radiosurgery; Micro-multileaf collimator; and Cerebral metastases.