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Cancer Watch

Cancer Cells Ablation with Irreversible Electroporation (p. 699-706)

In this study we perform in vitro irreversible electroporation (IRE) experiments with human hepatocarcinoma cells (HepG2) to investigate IRE as a new technique for undesirable tissue ablation. Irreversible electroporation (IRE) is the irreversible permeabilization of the cell membrane through the application of microsecond through millisecond electrical pulses. Until now IRE was studied only as an undesirable condition during the use of reversible electroporation in gene therapy and electrochemotherapy. There was a possibility that the IRE ablation domain is mostly superimposed on the electrical pulses induced Joule heating thermal ablation domain. This study demonstrates that there is a real and substantial domain of electrical parameters for IRE ablation of cancer that is distinct from the thermal domain and which results in complete cancer cell ablation. Experiments show that the application of 1500 V/cm in three sets of ten pulses of 300 microseconds each can produce complete cancer cell ablation. We also find that the use of multiple pulses appears to be more effective for cancer cell ablation than the application of the same energy in one single pulse.

Key words: Hepatic cancer; Irreversible electroporation; and Thermal effects.

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TCRT December 2005

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Volume 4
No. 6 (p 583-712)
December 2005
ISSN 1533-0338

Liron Miller, M.Sc.1
Jonathan Leor, M.D.1
Boris Rubinsky, Ph.D.2,*

1Neufeld Cardiac Research Institute
Sheba Medical Center
Tel-Aviv University
Tel-Hashomer 52621, Israel
2Department of Mechanical Engineering
Department of Bioengineering
University of California at Berkeley
Berkeley CA 94720, USA