TCRT December 2004

category image Volume 3
No. 6 (p 525-670)
December 2004
ISSN 1533-0338

Determination of Grade and Receptor Status from the Primary Breast Lesion by Magnetic Resonance Spectroscopy (p. 551-556)

Magnetic resonance spectra (MRS) from fine needle aspiration biopsies (FNAB) from primary breast lesions were analysed using a pattern recognition method, Statistical Classification Strategy, to assess tumor grade and oestrogen receptor (ER) and progesterone receptor (PgR) status. Grade 1 and 2 breast cancers were separated from grade 3 cancers with a sensitivity and specificity of 96% and 95%, respectively. The ER status was predicted with a sensitivity of 91% and a specificity of 90%, and the PgR status with a sensitivity of 91% and a specificity of 86%. These classifiers provide rapid and reliable, computerized information and may offer an objective method for determining these prognostic indicators simultaneously with the diagnosis of primary pathology and lymph node involvement.

Key words: Breast neoplasms, Fine needle aspiration spectroscopy (FNAS), Tumor grade, Receptor status, Magnetic resonance, Statistical analysis.

Cynthia Lean, Ph.D.1
Sinead Doran, B.Sc.1
Ray L. Somorjai, Ph.D.2
Peter Malycha, FRACS3
David Clarke, FRACS4
Uwe Himmelreich, Ph.D.1
Roger Bourne, Ph.D.1
Brion Dolenko, M.Sc.2
Alexander E. Nikulin, Ph.D.2
Carolyn Mountford, D.Phil.1,*

1Institute for Magnetic Resonance Research
Dept. of Magnetic Resonance in Medicine
University of Sydney
New South Wales 2006, Australia
2Institute for Biodiagnostics
National Research Council Canada
Winnipeg, Manitoba R3B 1Y6, Canada
3Department of Surgery
Royal Adelaide Hospital
University of Adelaide
South Australia 5000, Australia
4The Breast Center
6-8 Sydney St., Gateshead
New South Wales 2290, Australia
*caro@imrr.usyd.edu.au

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