TCRT December 2004No. 6 (p 525-670) December 2004 ISSN 1533-0338 Determination of Grade and Receptor Status from the Primary Breast Lesion by Magnetic Resonance Spectroscopy (p. 551-556)Magnetic resonance spectra (MRS) from fine needle aspiration biopsies (FNAB) from primary breast lesions were analysed using a pattern recognition method, Statistical Classification Strategy, to assess tumor grade and oestrogen receptor (ER) and progesterone receptor (PgR) status. Grade 1 and 2 breast cancers were separated from grade 3 cancers with a sensitivity and specificity of 96% and 95%, respectively. The ER status was predicted with a sensitivity of 91% and a specificity of 90%, and the PgR status with a sensitivity of 91% and a specificity of 86%. These classifiers provide rapid and reliable, computerized information and may offer an objective method for determining these prognostic indicators simultaneously with the diagnosis of primary pathology and lymph node involvement.
Key words: Breast neoplasms, Fine needle aspiration spectroscopy (FNAS), Tumor grade, Receptor status, Magnetic resonance, Statistical analysis. Cynthia Lean, Ph.D.1 1Institute for Magnetic Resonance Research Subscription is more cost effective than purchasing PDFs on-the-fly. Click here for details. |
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