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Cancer Watch
Optical Imaging section

Edited by Eva M. Sevick-Muraca, Ph.D. Polarized Reflectance Spectroscopy for Pre-Cancer Detection (p. 1-14)

Early detection of cancer and its curable precursors remains the best way to ensure patient survival and quality of life. Thus, highly selective, sensitive and cost-effective screening and diagnostic techniques to identify curable pre-cancerous lesions are desperately needed. Precancers are characterized by increased nuclear size, increased nuclear/cytoplasmic ratio, hyperchromasia and pleomorphism, which currently can only be assessed through an invasive, painful biopsy. Here, we describe the development of a non-invasive optical technique based on polarized reflectance spectroscopy that has the potential to provide in real time diagnostically useful information for pre-cancer detection. Our results demonstrate that polarized reflectance spectroscopy can be used to selectively detect the size-dependent scattering characteristics of nuclei in vivo. We gradually progress from cell suspensions to realistic three-dimensional tissue models of epithelium, then to cervical biopsies and, finally to in vivo studies on normal volunteers and clinical patients.




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TCRT February 2004

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Volume 3
No. 1 (p 1-92)
February 2004
ISSN 1533-0338

Konstantin Sokolov, Ph.D.1*
Linda T. Nieman, M.A.2
Alexey Myakov, M.S.3
Ann Gillenwater, M.D.4

1Department of Imaging Physics
M.D. Anderson Cancer Center
1515 Holcombe Blvd., Unit 56
Houston, TX 77030
2Department of Physics
The University of Texas at Austin
Austin, TX 78712
3Department of Biomedical Engineering
The University of Texas at Austin
Austin, TX 78712
4Department of Head and Neck Surgery
UT M.D. Anderson Cancer Center
Houston, TX 77030
*kostia@mail.utexas.edu